Kayla Forester, a young woman doing odd jobs, ends up bumping into Tom while he is chasing Jerry. During one of Tom's performances, Jerry picks a fight with him which ends with Tom's keyboard destroyed.
Tom, who dreams of becoming a pianist, plays in Central Park while Jerry is in search of a new home. After countless years of fighting, Tom Cat and Jerry Mouse go their separate ways and relocate to New York City for a fresh start.